Assessment of Awareness and Experience of Using off-label Drugs by Doctors of Clinical Specialties

Aim To evaluate the frequency of off-label prescription medicines in practice clinical specialists and awareness respondents procedure justified prescription. Material methods The sample included 542 who worked definite medical organizations 26 entities Russian Federation. were proposed to fill remotely an anonymous questionnaire experience prescribing adult patients. Results Prescribing not consistence with officially approved instruction for use (off-label or “outside instruction”) is a relevant issue global care since convincing scientific evidence safety such scarce. Analysis information about one current tasks national research centers according Federal Project “Development network implementation innovative technologies”. According responses prescriptions 67.5 % reported no prescription, 27.7 said “rarely” “sometimes”, 4.8 “frequently” “very frequently”. Specialties physicians have more often used (50% more) obstetrics gynecology, pediatrics, rheumatology, hematology, pulmonology. Cardiologists, neurologists pharmacologists relatively rarely (19.6%, 28.6 %, 22.2 respectively). 40 those designed treatment coronavirus infection SARS-CoV-2. most frequently metformin, rituximab, thioctic acid. 65 assessed their knowledge as insufficient. In addition, 75 consider it useful receive additional risks benefits practice. Conclusion survey revealed need